When President's only daughter, Liu Xin Ping, checked into the hospital for her chemotherapy treatment, the head of internal Medicine, Dr. Xu Da-Ming, and the head of surgery, Dr. Tang Guo-Tai, became the core members of the President's medical team. Both men planned to use this opportunity to prove themselves to be the best person for the hospital director's position.

Xu advised Liu to have a Central IV implantation to alleviate the discomfort of her treatment. He appointed Dr. Su Yi-Hua, an expert in this type of operation, to perform the surgery. When Tang found out, he was furious that Xu appointed one of his surgeons without his explicit approval. To spite Xu and take credit for the treatment, he replaced Su with Dr. Qiu Qing-Cheng and publicly announced that he himself had performed the surgery. However, this move put himself and the hospital in a very difficult position when Liu developed serious complications after the surgery.

Through out the ordeal, Su tried to maintain his integrity as a doctor by standing up to Tang. His actions created great displeasure in his boss and caused him to be alienated by the entire surgical department.

While Su was experiencing alienation, the woman he loved was also under duress in the hospital. Anesthesiologist Guan Xin was caught in a medical malpractice claim involving hospital director Huang Kai-Yuan. Through Tang, Huang put pressure on Guan to take the blame for the malpractice. Guan refused. In the ensuing media circus, Guan endured pressures from both the hospital and the victim's family. She learned that it's difficult to maintain principle in the face of reality.

Tang's overbearing attitude eventually led to his own downfall and Xu's rise to power. The shift in power stirred up series of personnel changes, of which, directly impacted the future of Qiu, Su and other members of the surgical department.

Cast
Hospital staff
* Jerry Yan as Su Yi Hua / 蘇怡華
* Leon Dai (戴立忍) as Qiu Qing Cheng / 邱慶成
* Ng Man Tat as Tang Guo Tai/唐國泰
* Janine Chang as Guan Xin / 關欣
* Chang Kuo Chu as Xu Da Ming / 徐大明
* Tang Zhi Ping as Chen Kuan / 陳寬
* Emma Ni (倪雅倫) as Secretary Yang
* Qian De Men as Zhao Zhong Ming / 趙仲銘
* Jason Chang as Hao Xiao Gang / 郝孝剛
* Zhang Fu Jian as Huang Kai Yuan / 黃凱元
* Tang Ke Hua (唐克華) as Ming Bin / 明濱
* Renzo Liu as Lai Cheng Xu / 賴成旭
* Linda Liao as Kang Wen Li/康雯麗 (Surgical Dept Head Nurse)
* Huang Zong You (黃宗祐) as Doctor Sun / 孫醫師
* Kelly Mi (米凱莉) as Wei Ming Zhu / 魏明珠 (Operation Room Head Nurse)

Family members of the staff
* Zhang Kui(張魁) as Chen Ting / 陳庭 (Chen Kuan's father)
* Shen Shi Hua as Tang Guo Tai's wife
* Ding Ning(丁寧) as Guan Hua / 關華 (Guan Xin's sister)
* Yang Wen Wen(楊文文) as Mei Qian / 美茜 (Qiu Qing Cheng's wife)
* Hong Cen (洪岑) as Qiu Min / 邱敏 (Qiu Qing Cheng's daughter)
* Ke Shu Qin(柯淑勤) as Xu Da Ming's wife
* Josephine Hsu as Xu Cui Feng 徐翠鳳 (Xu Da Ming's daughter)
* Jian Pei En as An Ni / 安妮 (Chen Kuan's wife)
* Wu Yan Xuan as Chen Xiang / 陳翔 (Chen Kuan's son)
* Qiu Nai Hua(秋乃華) as Ah Rui / 阿蕊

BTV Journalists
* Cheryl Yang as Ma Yi Fen / 馬懿芬
* Yao Dai Wei(姚黛瑋) as Chang Yi Ru / 常憶如

Patients and their relations
* Saya as Liu Xin Ping / 劉心萍 (president's daughter)
* Liang Xiu Shen(梁修身) as President Liu
* Deng An Ning(鄧安寧) as Wang Shi Ping / 王世平 (President's Secretary)
* Lin Li Yang as Deng Nian Wei / 鄧念瑋 (Zhu Hui Ying's husband)
* Shen Hai Rong(沈海蓉) as Zhu Hui Ying's mother
* Xiang Li Wen(向麗雯) as Zhu Hui Ying / 朱慧瑛
* Cai Mi Jie(蔡宓潔) as Zhu Hui Ting / 朱慧婷
* Agnes Monica as Zhang Mei Xin ( Su Yi Hua's patient )

Others
* Kris Phillips(費翔) as Zhuang Ming Zhe / 莊明哲
* Xiu Jie Kai as Liao Qi Shu / 廖其書
* Tender Huang(黃騰德) as Hong Wei / 洪威 (Guan Xin's Lawyer)
* Huang Ruo Bai(黃若白) as Principal Sun / 孫校長
* Tao Chuan Zheng(陶傳正) as Manager Fang