Honey and Clover follows the lives of five college students and their love triangles.


Cast
* Narumi Riko as Hanamoto Hagumi
* Ikuta Toma as Takemoto Yuta
* Harada Natsuki as Yamada Ayumi
* Mukai Osamu as Mayama Takumi
* Narimiya Hiroki as Morita Shinobu
* Takizawa Saori as Teshigawara Miwako
* Kimura Yuichi as Lohmeyer-senpai
* Matsushige Yutaka as Professor Shoda
* Maekawa Yasuyuki as Teranobori Yasuhiko
* Kashiwabara Takashi as Nomiya Takumi
* Izumiya Shigeru as Yamada Daigoro
* Murakami Jun as Hanamoto Shuji
* Seto Asaka as Harada Rika

Guests
* Sanada Seiya (真田聖也) (ep1)
* Ishikawa Yuya (石川雄也) (ep1-9)
* Tsuchiya Fumiko (土屋史子) (ep1-9)
* Kaito Ken as Harada Hideyuki (ep2-3,6,8)
* Waki Tomohiro (ep2-5,7-8)
* Korechika Atsushi (ep2-5,7-8)
* Gan Kyotaro (眼鏡太郎) (ep2-5,7-8)
* Okawara Akira (大河原晃) (ep2-5,7-8)
* Tokunaga Jun (徳永淳) (ep2)
* Sakurada Seiko (ep2)
* Sugao Nagisa (菅尾なぎさ) (ep2)
* Akiyama Yusuke (秋山悠介) (ep2)
* Nagano Satomi (長野里美) (ep3)
* Shimazu Kentaro (島津健太郎) (ep3)
* Morohashi Reiko (諸橋玲子) (ep3)
* Imai Koji (今井耕二) (ep3)
* Shono Yoko (生野陽子) (ep4)
* Christopher Mae (ep4-5)
* Nishitate Saori (西舘さをり) (ep4)
* Kobayashi Natsuko (小林夏子) (ep4)
* Asanuma Taiki (浅沼太貴) (ep4)
* Wakabayashi Yuya (若林佑弥) (ep4)
* Takahashi Hitomi as Professor Ogami (ep4,6-9)
* Hashimoto Jun as Aida Kazuo (ep5-6,8)
* Kotoh Lorena (估藤ロレナ) (ep5)
* Aizawa Ryusei (相澤瑠星) (ep5)
* Nakamaru Shinsho as the interviewer (ep6)
* Nakamura Yasuhi (ep6)
* Sunaga Kei (ep6)
* Otake Koichi (大竹浩一) (ep6)
* Kogure Kuniaki (小暮邦明) (ep6)
* Minami Yoshihiro (南好洋) (ep6)
* Taira Chiharu (平良千春) (ep6)
* Miyanari Ryuji (宮成竜二) (ep6)
* Suzuki Akinofu (鈴木アキノフ) (ep6)
* Hamada Gaku as Rokutaro (ep8,11)
* Yamanaka So (山中聡) as Shin-san (ep8,10-11)
* Yoshikawa Fumiki (吉川史樹) (ep8)
* Shimizu Shogo as the master woodworker (ep8)
* Akaya Banmei (赤屋板明) (ep9)
* Meguri Tobio (廻飛雄) (ep9)
* Ebihara Keisuke (海老原敬介) (ep10-11)
* Ito Mizuki (伊藤瑞稀) (ep10-11)
* Hiwatashi Shinji (樋渡真司) (ep11)